Snake bites were frequent in men (75.1%), rural workers (65.1%), literate individuals (69%) between 11 and 20 years-old (21.7%), and toes the most common area attacked (52.7%). RESULTS: The genera Bothrops and Bothropoides caused 91.7% of the ophidic accidents reported. All of the patients admitted had medical diagnoses and were monitored at Ceatox-CG or Ceatox-JP. METHODS: This is a prospective and transverse study, following a quantitative approach of accidents involving Bothrops and Bothropoides admitted to the Toxicological Assistance and Information Centers of Campina Grande and João Pessoa (Ceatox-CG and Ceatox-JP), aimed at identifying the epidemiological and clinical profile of such accidents. The species that cause ophidic accidents in State of Paraíba are Bothropoides erythromelas, Bothrops leucurus and Bothropoides neuwiedi. INTRODUCTION: Bothrops and Bothropoides snakes cause 70% of the ophidic accidents in Brazil. VIAgronomy Graduate Program, Universidade Federal da Paraíba, João Pessoa, PB, Brazil VCentro de Atendimento Toxicológico, Campina Grande, PB IVPharmacy Departement, Universidade Estadual da Paraíba, João Pessoa, PB, Brazil IIIPharmacology Graduate Program, Universidade Federal do Ceará, Fortaleza, CE, Brazil IINatural Products and Bioactive Synthetics Graduate Program, Universidade Federal da Paraíba, João Pessoa, PB, Brazil IHealth Sciences Graduate Program, Universidade de Brasília, Brasília, DF, Brazil This is particularly important when covariate effects exist that may affect the outcome of a trial.Accidents caused by Bothrops and Bothropoides in the State of Paraiba: epidemiological and clinical aspectsĪcidentes causados por serpentes dos gêneros Bothrops e Bothropoides no Estado da Paraíba: aspectos clínicos e epidemiológicosįagner Neves Oliveira I Monalisa Taveira Brito II Isabel Cristina Oliveira de Morais III Sayonara Maria Lia Fook IV Helder Neves de Albuquerque V, VI However, in order to obtain realistic simulation scenarios, the patients included in the CTS process must be representative of the target population.
#THE PAINA 95.9 TRIAL#
P2 THE COMBINED EFFECT OF DIAZEPAM AND VERAPAMIL ON TRACHEAL RESPONSE CAUSED BY ACETYLCHOLINE AND HISTAMINE IN GUINEA PIGS ´ ´ ´ Mitic R.1, Damjanovic J.2, Stanojevic Z.1 1 Medical faculty Pristina, Kosovska Mitrovica, Serbia 2The MathematiË cal High School, Belgrade, Serbia Objectives: Clinical Trial Simulation (CTS) can be a valuable tool to improve drug development. Journal of Pharmacokinetics and Pharmacodynamics. (2006) Simulation of Correlated Continuous and Categorical Variables using a Single Multivariate Distribution.
E.1,2 1 Division of Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden, The Netherlands 2Clinical Pharmacology Modelling & Simulation, GlaxoSmithKline, UK 3Department of Pharmacometrics, Nycomed GmbH, Konstanz, Germany 2. J.2, Facius A.3, Yang S.2, Danhof M.1, Della Pasqua O. P1 MULTIVARIATE PATIENT SIMULATION FOR CLINICAL TRIAL OPTIMIZATION IN COPD Teutonico D.1, Musuamba F.1, Maas H. Basic and Clinical Pharmacology & Toxicology Wiley The objective of this exercise is to evaluate the performance of different methods to simulate demographic covariates of patients for a Chronic Obstructive Pulmonary Disease (COPD)
This is particularly important when covariate effects exist that may affect the outcome of a trial.
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